Wilcox R E, Levitt R A
Pharmacol Biochem Behav. 1978 Oct;9(4):425-8. doi: 10.1016/0091-3057(78)90035-7.
The narcotic antagonist, naloxone, was microinjected into the head of the caudate nucleus (HC), periaqueductal gray matter (PG), and cerebellar white matter (CB) of rats to counteract the catatonia induced by systemic morphine. Naloxone produced a loss of the catatonic response when administered into HC or PG, but not when microinjected into CB. Isotonic saline in HC, PG, and CB did not counteract the catatonic effects of morphine. The reversal of catatonia was similar for naloxone injections in HC and PG. Both these areas have high concentrations of opiate receptors while CB has few opiate receptors. It is suggested that the HC and PG are involved in the reversal of the catatonic effects of morphine via the high concentrations of opiate receptors found there.
将麻醉拮抗剂纳洛酮微量注射到大鼠的尾状核头部（HC）、导水管周围灰质（PG）和小脑白质（CB）中，以对抗全身注射吗啡引起的紧张症。当注入HC或PG时，纳洛酮可使紧张症反应消失，但微量注射到CB时则不会。在HC、PG和CB中注射等渗盐水不能对抗吗啡的紧张症作用。在HC和PG中注射纳洛酮后，紧张症的逆转情况相似。这两个区域都有高浓度的阿片受体，而CB的阿片受体很少。提示HC和PG通过其中发现的高浓度阿片受体参与了吗啡紧张症作用的逆转。
