Bousso P, Kourilsky P
Unité de Biologie Moléculaire du Gène, INSERM U277, Institut Pasteur, 25 rue du Dr Roux, Paris, Cedex 15, 75015-75724, France.
Semin Immunol. 1999 Dec;11(6):423-31. doi: 10.1006/smim.1999.0200.
Quantitative analyses of antigen (Ag)-specific alphabeta T cell populations have provided a large body of information on the natural course of T cell immune responses. New tools are now available to determine the clonal composition of Ag-specific pools in individual responders, an approach which offers direct insights into the generation of T cell immune responses and establishment of protective immunity. The present review discusses the parameters that determine the composition of Ag-specific T cell responses. Emphasis is placed on the role of the naive alphabeta T cell repertoire and on the dynamics of individual Ag-specific T cell clones during the successive phases of an immune response.
对抗原（Ag）特异性αβ T细胞群体的定量分析为T细胞免疫反应的自然进程提供了大量信息。现在有了新工具来确定个体应答者中Ag特异性库的克隆组成，这种方法能直接深入了解T细胞免疫反应的产生以及保护性免疫的建立。本综述讨论了决定Ag特异性T细胞反应组成的参数。重点在于初始αβ T细胞库的作用以及免疫反应连续阶段中单个Ag特异性T细胞克隆的动态变化。
