Fermand J P, Brouet J C
Department of Immuno-Hematology, Hôpital Saint-Louis, Paris, France.
Hematol Oncol Clin North Am. 1999 Dec;13(6):1281-94. doi: 10.1016/s0889-8588(05)70127-1.
This review underscores the diversity of the structural and genetic abnormalities of HCD proteins and of the clinicopathologic features of the underlying lymphoproliferative disorders. Cells producing HCD may, however, all derive from a common normal precursor, which could be a rare B cell in the process of immunoglobulin gene somatic mutation within the germinal center.
本综述强调了重链病（HCD）蛋白结构和基因异常以及潜在淋巴增殖性疾病临床病理特征的多样性。然而，产生HCD的细胞可能都来源于一个共同的正常前体细胞，该前体细胞可能是生发中心内处于免疫球蛋白基因体细胞突变过程中的一种罕见B细胞。
