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Structure of HLA antigens: amino-acid and carbohydrate compositions and NH2-terminal sequences of four antigen preparations.HLA抗原的结构：四种抗原制剂的氨基酸和碳水化合物组成以及氨基末端序列
Proc Natl Acad Sci U S A. 1976 Mar;73(3):910-4. doi: 10.1073/pnas.73.3.910.
2
Comparative chemical analyses and partial amino acid sequences of the heavy chains of HL-A antigens.HL - A抗原重链的比较化学分析和部分氨基酸序列
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3
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4
Purification and structural characterisation of human HLA-linked B-cell antigens.人类HLA连锁B细胞抗原的纯化与结构表征
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5
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9
The B multigene family of chorion proteins in saturniid silkmoths.天蚕蛾中绒毛蛋白的B多基因家族。
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10
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Spectroscopic determination of tryptophan and tyrosine in proteins.蛋白质中色氨酸和酪氨酸的光谱测定
Biochemistry. 1967 Jul;6(7):1948-54. doi: 10.1021/bi00859a010.
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The estimation of polypeptide chain molecular weights by gel filtration in 6 M guanidine hydrochloride.在6M盐酸胍中通过凝胶过滤法估算多肽链分子量
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4
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
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Construction of phylogenetic trees.系统发育树的构建。
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Initiation of protein synthesis at an unusual position in an immunoglobulin gene?免疫球蛋白基因中在一个不寻常位置起始蛋白质合成？
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7
Thin-layer chromatography of sub-nanomole amounts of phenylthiohydantoin (PTH) amino acids on polyamide sheets.在聚酰胺薄板上对亚纳摩尔量的苯硫基乙内酰脲（PTH）氨基酸进行薄层色谱分析。
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8
2 -Microglobulin--a free immunoglobulin domain.β2微球蛋白——一种游离免疫球蛋白结构域。
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1697-701. doi: 10.1073/pnas.69.7.1697.
9
Papain-solubilized HL-A antigens from cultured human lymphocytes contain two peptide fragments.从培养的人淋巴细胞中用木瓜蛋白酶溶解的HL-A抗原含有两个肽片段。
Proc Natl Acad Sci U S A. 1973 May;70(5):1603-7. doi: 10.1073/pnas.70.5.1603.
10
The low polarity of many membrane proteins.许多膜蛋白的低极性。
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HLA抗原的结构：四种抗原制剂的氨基酸和碳水化合物组成以及氨基末端序列

Structure of HLA antigens: amino-acid and carbohydrate compositions and NH2-terminal sequences of four antigen preparations.

作者信息

Terhorst C, Parham P, Mann D L, Strominger J L

出版信息

Proc Natl Acad Sci U S A. 1976 Mar;73(3):910-4. doi: 10.1073/pnas.73.3.910.

DOI:10.1073/pnas.73.3.910
PMID:1062804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC336029/
Abstract

Amino-acid and carbohydrate compositions in addition to limited NH2-terminal sequence data of four preparations of HLA antigens, including products of both of the major histocompatibility loci (HLA-A and HLA-B), show that the antigens have great homology in the primary structure. A striking observation is that HLA antigens also have a considerable structure homology with mouse H-2 antigens. HLA antigens appear to have one carbohydrate side chain which has the same composition in all four cases. The possible relation of the structure of the heavy chain of HLA antigens to immunoglobulins is discussed, based on the limited data which are available so far.

摘要

除了四种HLA抗原制剂（包括两个主要组织相容性位点HLA - A和HLA - B的产物）的有限氨基末端序列数据外，氨基酸和碳水化合物组成表明这些抗原在一级结构上具有高度同源性。一个显著的观察结果是，HLA抗原与小鼠H - 2抗原在结构上也有相当的同源性。HLA抗原似乎有一个碳水化合物侧链，在所有四种情况下其组成相同。基于目前可用的有限数据，讨论了HLA抗原重链结构与免疫球蛋白的可能关系。