Spurr N K, Solomon E, Jansson M, Sheer D, Goodfellow P N, Bodmer W F, Vennstrom B
EMBO J. 1984 Jan;3(1):159-63. doi: 10.1002/j.1460-2075.1984.tb01777.x.
Avian erythroblastosis virus (AEV) induces acute erythroleukemia and sarcomas in vivo and it transforms erythroblasts and fibroblasts in vitro. The virus has two host cell-derived genes, v-erbA and v-erbB. The latter encodes the oncogenic capacity of the virus, whereas v-erbA enhances the erythroblast transforming effects of v-erbB while being unable to induce neoplasms independently. Recently, human cellular homologues of these viral erb genes have been isolated. The chromosomal locations of two of these genes have been determined using EcoRI-digested DNA prepared from human-mouse somatic cell hybrids. The human c-erbA1 gene has been assigned to chromosome 17 and is located between 17p11 and 17q21. The human c-erbB sequence has been assigned to chromosome 7 and is located between 7pter and 7q22. Thus, in the human genome these genes are on two separate chromosomes. No evidence for the involvement of the human c-erb genes in neoplasia has been found.
禽成红细胞增多症病毒（AEV）在体内可诱发急性成红细胞白血病和肉瘤，在体外可转化成红细胞和纤维母细胞。该病毒有两个源自宿主细胞的基因，即v-erbA和v-erbB。后者编码病毒的致癌能力，而v-erbA虽无法独立诱发肿瘤，但可增强v-erbB对成红细胞的转化作用。最近，已分离出这些病毒erb基因的人类细胞同源物。利用从人-鼠体细胞杂种制备的经EcoRI酶切的DNA，已确定其中两个基因在染色体上的位置。人类c-erbA1基因已被定位于17号染色体，位于17p11和17q21之间。人类c-erbB序列已被定位于7号染色体，位于7pter和7q22之间。因此，在人类基因组中，这些基因位于两条不同的染色体上。尚未发现人类c-erb基因参与肿瘤形成的证据。
