Muraguri G R, Kiara H K, McHardy N
National Veterinary Research Centre, Kenya Agricultural Research Institute, Kikuyu, Kenya.
Vet Parasitol. 1999 Nov;87(1):25-37. doi: 10.1016/s0304-4017(99)00154-5.
Two trials were conducted to compare the efficacy of parvaquone and buparvaquone for the treatment of naturally acquired East Coast fever (ECF, Theileria parva infection) which, if untreated, is almost invariably fatal in European breeds of cattle. In the first trial 28 naive cattle were exposed in a paddock infested with ticks carrying a virulent form of the disease. Twelve were treated with each drug when they developed clinical ECF. All 24 cattle were cured. In the second study, 100 cases of ECF occurring naturally on farms in Kenya were treated, 50 with each drug. Parvaquone cured 44 (88%) buparvaquone cured 45 (90%). Intercurrent infections, predominantly anaplasmosis and bacterial pneumonia or scour, were treated specifically. It is concluded that parvaquone and buparvaquone are similarly effective in curing ECF and cure rates are maximised by accurate diagnosis and prompt treatment of both ECF and intercurrent infections.
进行了两项试验，以比较帕伐醌和丁萘醌治疗自然感染东海岸热（ECF，小泰勒虫感染）的疗效。东海岸热如果不治疗，在欧洲品种的牛中几乎总是致命的。在第一项试验中，28头未接触过该病的牛被放置在一个有携带该病强毒株蜱虫的牧场中。当它们出现临床东海岸热症状时，12头牛分别用这两种药物进行治疗。所有24头牛均被治愈。在第二项研究中，对肯尼亚农场自然发生的100例东海岸热病例进行了治疗，每种药物治疗50例。帕伐醌治愈了44例（88%），丁萘醌治愈了45例（90%）。对同时发生的感染，主要是无形体病、细菌性肺炎或腹泻，进行了针对性治疗。得出的结论是，帕伐醌和丁萘醌在治愈东海岸热方面同样有效，通过准确诊断以及对东海岸热和同时发生的感染进行及时治疗，可使治愈率最大化。
