Dolan T T, Injairu R, Gisemba F, Maina J N, Mbadi G, Mbwiria S K, Mulela G H, Othieno D A
International Laboratory for Research on Animal Diseases, Nairobi, Kenya.
Vet Rec. 1992 Jun 13;130(24):536-8. doi: 10.1136/vr.130.24.536.
A clinical trial was conducted to test buparvaquone (Butalex; Coopers Pitman-Moore) in the treatment of East Coast fever under field conditions in Kenya. Data from 229 cases were analysed following treatment with one (69), two (142) or three (18) doses at 2.5 mg/kg. The majority of cattle (95.2 per cent) were exotic (Bos taurus) or improved (Bos taurus cross Bos indicus) and 39.3 per cent were infected with Anaplasma marginale. There was an overall recovery rate of 85.6 per cent, with 90.1 per cent recovering following one treatment and 75.4 per cent recovering following two treatments. At a follow-up visit three to six months after completion of the trial data was obtained on 224 cases. Thirty had died, 13 of which were reported to have been from East Coast fever, nine had been sold and six slaughtered. Of the remaining 146, 86.3 per cent were in good condition, 13.7 per cent fair and 2.0 per cent in poor condition. A two dose regimen was most effective and should be recommended except in very early cases or those under direct veterinary supervision.
在肯尼亚的实地条件下进行了一项临床试验，以测试丁喹酯（Butalex；库珀斯皮特曼 - 摩尔公司）治疗东海岸热的效果。对229例病例的数据进行了分析，这些病例接受了2.5毫克/千克剂量的一次（69例）、两次（142例）或三次（18例）治疗。大多数牛（95.2%）为外来品种（Bos taurus）或改良品种（Bos taurus与Bos indicus的杂交品种），39.3%的牛感染了边缘无浆体。总体恢复率为85.6%，一次治疗后的恢复率为90.1%，两次治疗后的恢复率为75.4%。在试验结束三至六个月后的随访中，获得了224例病例的数据。30头牛死亡，其中13例据报告死于东海岸热，9例已售出，6例被屠宰。在其余146头牛中，86.3%状况良好，13.7%中等，2.0%状况不佳。两剂治疗方案最为有效，除极早期病例或在兽医直接监督下的病例外，均应推荐使用。
