Shu F, Sugimura M, Kanayama N, Kobayashi H, Kobayashi T, Terao T
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Gynecol Obstet Invest. 2000;49(1):17-23. doi: 10.1159/000010206.
We investigated the clinical significance of annexin V in the placentae with preeclampsia and found: (1) annexin V was detected on trophoblasts in the placentae and the staining intensity of annexin V in the placentae from such patients was reduced when compared to normal placentae; (2) as expression of annexin V was reduced, the gestosis index from patients with preeclampsia was elevated and the standard deviation value in the infant's standard weight was decreased; plasma level of the fibrin degradation products and thrombin-antithrombin III complex from patients were elevated as the expression of anexin V was reduced. These results suggest that the reduced expression of annexin V in the placentae from patients with preeclampsia may lead to a hypercoagulable state in the intervillous space and may be associated with the development of intrauterine growth restriction.
我们研究了膜联蛋白V在子痫前期胎盘组织中的临床意义，发现：（1）在胎盘的滋养层细胞上可检测到膜联蛋白V，与正常胎盘相比，此类患者胎盘组织中膜联蛋白V的染色强度降低；（2）随着膜联蛋白V表达降低，子痫前期患者的妊娠中毒指数升高，婴儿标准体重的标准差降低；随着膜联蛋白V表达降低，患者血浆中纤维蛋白降解产物和凝血酶-抗凝血酶III复合物水平升高。这些结果表明，子痫前期患者胎盘组织中膜联蛋白V表达降低可能导致绒毛间隙出现高凝状态，并可能与胎儿宫内生长受限的发生有关。
