Department of Obstetrics and Gynecology, University of Milano-Bicocca, Via Pergolesi 33, 20052 Monza, Italy.
Placenta. 2011 Mar;32(3):264-8. doi: 10.1016/j.placenta.2010.12.015. Epub 2011 Jan 7.
To study the expression of Annexin A5 (A5) in relation to preeclampsia using immunohistochemical Tissue Microarray (TMA) technique.
Case-control study of 66 singleton preeclamptic (PE) patients matched for gestational age (GA) at delivery with 63 normotensive controls with normally grown fetuses. Immunohistochemical expression of A5 and other population characteristics were compared between the two groups using Chi-square, One-way ANOVA, Spearman's Correlation, and Linear Regression.
The two groups were similar for maternal age and rate of corticosteroid administration, but differed for nulliparity, Body Mass Index (BMI), blood pressure, presence of placental histological lesions, and placental weight. Expression of A5 was similar in PE and controls (p = 0.10); however it was found to be lower in PE cases complicated by fetal growth restriction (FGR, n = 34) compared with matched controls (n = 55) (p = 0.04). An inverse correlation was found between A5 and GA in cases but not in controls (p = 0.04 vs p = 0.71). The association was even more significant in the subgroup of PE complicated by FGR (p = 0.02). A5 expression was not influenced by blood pressure, proteinuria, or placental weight.
Annexin A5 expression seems to be related only to FGR and not to PE or its clinical severity.
使用免疫组织化学组织微阵列（TMA）技术研究 Annexin A5（A5）在子痫前期中的表达。
对 66 例单胎子痫前期（PE）患者进行病例对照研究，按分娩时的孕龄（GA）与 63 例正常胎儿生长的正常血压对照组相匹配。使用卡方检验、单因素方差分析、斯皮尔曼相关性和线性回归比较两组之间 A5 的免疫组织化学表达和其他人群特征。
两组在母亲年龄和皮质类固醇使用率方面相似，但在初产妇、体重指数（BMI）、血压、胎盘组织学病变和胎盘重量方面存在差异。PE 和对照组之间 A5 的表达相似（p=0.10）；然而，与匹配的对照组（n=55）相比，PE 合并胎儿生长受限（FGR，n=34）病例中 A5 的表达较低（p=0.04）。在病例中发现 A5 与 GA 之间存在负相关，但在对照组中则没有（p=0.04 与 p=0.71）。在 PE 合并 FGR 的亚组中，这种关联更加显著（p=0.02）。A5 的表达不受血压、蛋白尿或胎盘重量的影响。
A5 表达似乎仅与 FGR 相关，而与 PE 或其临床严重程度无关。
