Kinnunen R E, Tallberg T, Stenbäck H, Sarna S
Veterinary Clinic, Nummela, Finland.
Anticancer Res. 1999 Jul-Aug;19(4C):3367-74.
Twenty-one horses with sarcoid tumours were treated by bio-immunotherapy using autogenous vaccines during 1991-1997. At operation the base of the tumour was left in the skin and autovaccines were made from extirpated tumour tissue by polymerization. The horses thus formed their own internal control group. One of 12 horses having a primary tumour, and four of 9 horses suffering recurrent tumours, prior to bio-immunotherapy, developed single recurrences. Four of these five horses suffering recurrence were treated anew, leading to remission. Disease-free intervals were longer for primary (P = 0.0005) and recurrent sarcoids (P = 0.0156) than for conventional surgery alone. Mitochondrial events seem to effect the healing.
1991年至1997年期间，对21匹患有肉瘤样肿瘤的马采用自体疫苗进行生物免疫治疗。手术时，肿瘤基底留在皮肤内，通过聚合从切除的肿瘤组织制备自体疫苗。这些马因此形成了它们自己的内部对照组。在生物免疫治疗前，12匹患有原发性肿瘤的马中有1匹，9匹患有复发性肿瘤的马中有4匹出现了单发复发。这5匹复发的马中有4匹再次接受治疗，病情缓解。原发性（P = 0.0005）和复发性肉瘤样肿瘤（P = 0.0156）的无病间期比单纯传统手术更长。线粒体事件似乎影响愈合。
