来自酸枣的具有抗菌活性的新型三萜类化合物。

New triterpenoids with antibacterial activity from Zizyphus joazeiro.

作者信息

Schühly W, Heilmann J, Calis I, Sticher O

机构信息

Department of Pharmacy, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland.

出版信息

Planta Med. 1999 Dec;65(8):740-3. doi: 10.1055/s-1999-14054.

DOI:10.1055/s-1999-14054

PMID:10630117

Abstract

The stem bark of the Brazilian medicinal plant Zizyphus joazeiro C. Mart. was phytochemically investigated. Three known compounds (betulinic, ursolic and alphitolic acid) and three new derivatives of betulinic acid, 7 beta-(4-hydroxybenzoyloxy)-betulinic acid, 7 beta-(4-hydroxy-3'-methoxybenzoyloxy)-betulinic acid and 27-(4-hydroxy-3'-methoxybenzoyloxy)-betulinic acid which showed a considerable activity against Gram-positive bacteria were isolated from the dichloromethane extract. The structures were established on the basis of NMR spectroscopy and mass spectrometry.

摘要

对巴西药用植物枣（Zizyphus joazeiro C. Mart.）的茎皮进行了植物化学研究。从二氯甲烷提取物中分离出三种已知化合物（桦木酸、熊果酸和α-香树脂酸）以及桦木酸的三种新衍生物，即7β-(4-羟基苯甲酰氧基)-桦木酸、7β-(4-羟基-3'-甲氧基苯甲酰氧基)-桦木酸和27-(4-羟基-3'-甲氧基苯甲酰氧基)-桦木酸，这些化合物对革兰氏阳性菌显示出相当强的活性。其结构通过核磁共振光谱和质谱得以确定。