Fanshawe M P
Department of Anaesthesia and Intensive Care, Redcliffe Hospital, Brisbane, Queensland.
Anaesth Intensive Care. 1999 Dec;27(6):610-4. doi: 10.1177/0310057X9902700609.
This double-blind, randomized study of analgesia after caesarean section compared patient controlled epidural analgesia with pethidine (15 mg of a 0.25% solution and a 10 minute lockout period) versus a single bolus of epidural morphine 4 mg. Data were collected on 78 patients at 2, 6, 8, and 24 hours postoperatively and analysed using the Wilcoxon rank sum test. Satisfactory analgesia and nausea/vomiting during the first twenty-four hours did not differ between the two groups. The incidence of pruritus (P < 0.001) was lower in the pethidine group at 2, 6, and 8 hours, with no difference by 24 hours. Therefore PCEA pethidine provides a useful alternative to single-dose morphine after caesarean section, particularly in those patients who have suffered severe morphine-induced pruritus previously.
这项关于剖宫产术后镇痛的双盲随机研究,将患者自控硬膜外镇痛与哌替啶(15毫克0.25%溶液,锁定时间10分钟)对比,后者与单次硬膜外注射4毫克吗啡。术后2、6、8和24小时收集了78例患者的数据,并使用Wilcoxon秩和检验进行分析。两组在术后头24小时的镇痛效果和恶心/呕吐情况无差异。哌替啶组在2、6和8小时瘙痒发生率较低(P<0.001),24小时时无差异。因此,剖宫产术后患者自控硬膜外注射哌替啶是单剂量吗啡的有效替代方法,尤其适用于那些先前曾遭受严重吗啡诱发瘙痒的患者。