Goh J L, Evans S F, Pavy T J
Department of Anaesthesia, King Edward Memorial Hospital, Subiaco, W.A.
Anaesth Intensive Care. 1996 Feb;24(1):45-50. doi: 10.1177/0310057X9602400108.
Pethidine and fentanyl have both been used to provide patient-controlled epidural analgesia (PCEA) following caesarean delivery. Both have been compared with epidural morphine but these drugs have not been compared with each other. Patient-controlled epidural analgesia was used in a prospective, randomized, double-blind, cross-over trial to compare fentanyl and pethidine for postoperative epidural analgesia in women having elective caesarean deliveries. Two groups received either PCEA fentanyl or pethidine with a cross-over to the other drug after 24 hours. Results from 45 patients showed no difference in pain level outcomes, but pethidine scored better in all side-effects except for drowsiness at 48 hours. Patients were more satisfied with pethidine (P = 0.015) and overall 65% of patients preferred pethidine. We conclude that pethidine is a suitable drug for patient-controlled epidural analgesia and leads to greater patient satisfaction than does fentanyl.
哌替啶和芬太尼都曾用于剖宫产术后的患者自控硬膜外镇痛（PCEA）。二者均已与硬膜外吗啡进行过比较，但这两种药物之间尚未进行过对比。在一项前瞻性、随机、双盲、交叉试验中，采用患者自控硬膜外镇痛来比较芬太尼和哌替啶对择期剖宫产术后女性的硬膜外镇痛效果。两组分别接受PCEA芬太尼或PCEA哌替啶治疗，24小时后交叉使用另一种药物。45例患者的结果显示，疼痛水平结果无差异，但除48小时时的嗜睡外，哌替啶在所有副作用方面的评分更高。患者对哌替啶更满意（P = 0.015），总体上65%的患者更喜欢哌替啶。我们得出结论，哌替啶是患者自控硬膜外镇痛的合适药物，与芬太尼相比能带来更高的患者满意度。
