小鼠的干扰素治疗：淋巴细胞上组织相容性抗原的表达增强。
Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells.
作者信息
Lindahl P, Gresser I, Leary P, Tovey M
出版信息
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1284-7. doi: 10.1073/pnas.73.4.1284.
Abstract
Treatment of young and mature mice with potent mouse interferon preparations results in a marked enhancement of the expression of histocompatibility antigens on the surface of thymocytes and splenic lymphocytes as measured by an enhanced absorption of alloantiserum. We postulate that such modifications of the cell surface may reflect an effect of interferon on lymphocyte maturation and may be relevant to the effect of interferon on lymphocyte function.
摘要
用高效的小鼠干扰素制剂处理幼年和成年小鼠，结果显示，通过同种异体抗血清吸收增强来测定，胸腺细胞和脾淋巴细胞表面的组织相容性抗原表达显著增强。我们推测，细胞表面的这种改变可能反映了干扰素对淋巴细胞成熟的影响，并且可能与干扰素对淋巴细胞功能的影响有关。
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本文引用的文献
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Antitumour effect of lymphoid cells activated by interferon.干扰素激活的淋巴细胞的抗肿瘤作用。
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Effects of interferon on antibody synthesis in vitro.干扰素对体外抗体合成的影响。
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Immunosuppressive effects of an interferon preparation in vivo.一种干扰素制剂在体内的免疫抑制作用。
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Suppression of mouse antibody producing spleen cells by various interferon preparations.各种干扰素制剂对小鼠抗体产生脾细胞的抑制作用。
Nature. 1973 Nov 9;246(5428):92-4. doi: 10.1038/246092a0.
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Inhibitory effect of interferon preparations and inducers on the multiplication of transplanted allogeneic spleen cells and syngeneic bone marrow cells.干扰素制剂和诱导剂对移植的同种异体脾细胞和同基因骨髓细胞增殖的抑制作用。
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