Lindahl P, Leary P, Gresser I
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2785-8. doi: 10.1073/pnas.70.10.2785.
Preparations of mouse interferon enhanced the expression of surface antigens of murine leukemia L 1210 cells, as determined by their alloantibody-absorbing capacity. The factor responsible for the enhancement of surface antigen expression could not be dissociated from the antiviral activity of interferon by standard physicochemical means. Likewise, interferon did not increase the antibody-absorbing capacity of an interferon-resistant subline of L 1210 cells. We conclude that interferon treatment of L 1210 cells is accompanied by modifications of the cell surface.
通过小鼠白血病L 1210细胞的同种抗体吸收能力测定,小鼠干扰素制剂增强了该细胞表面抗原的表达。通过标准物理化学方法,负责增强表面抗原表达的因子无法与干扰素的抗病毒活性分离。同样,干扰素也没有增加L 1210细胞的一个干扰素抗性亚系的抗体吸收能力。我们得出结论,对L 1210细胞进行干扰素处理会伴随着细胞表面的改变。