Bozdag O, Verspohl E J, Ertan R
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
Arch Pharm (Weinheim). 1999 Dec;332(12):435-8. doi: 10.1002/(sici)1521-4184(199912)332:12<435::aid-ardp435>3.0.co;2-l.
A new series of flavonyl-3'-sulphonylurea derivatives (1-7) was prepared by reaction of several isocyanates with flavone-3'-sulphonamide (III). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds 1 and 4 were able to increase insulin release in the presence of 8.3 mM glucose at least at the higher concentrations used.
通过几种异氰酸酯与黄酮-3'-磺酰胺（III）反应制备了一系列新的黄酮基-3'-磺酰脲衍生物（1-7）。对所制备的化合物在INS-1细胞中进行促胰岛素分泌活性测试。化合物1和4至少在所用的较高浓度下，能够在8.3 mM葡萄糖存在的情况下增加胰岛素释放。
