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某些取代黄酮基噻唑烷二酮衍生物的合成及降血糖活性——第五篇通讯：黄酮基苄基取代的2,4-噻唑烷二酮

Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives--fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones.

作者信息

Tunçbilek Meral, Bozdağ-Dündar Oya, Ayhan-Kilcigil Gülgün, Ceylan Meltem, Waheed Abdül, Verspohl Eugen J, Ertan Rahmiye

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Turkey.

出版信息

Farmaco. 2003 Jan;58(1):79-83. doi: 10.1016/S0014-827X(02)01241-7.

DOI:10.1016/S0014-827X(02)01241-7
PMID:12595040
Abstract

A new series of 3-benzyl(p-substituted benzyl)-5-[3'-(4H-4-oxo-1-benzopyran-2-yl)-benzylidene]-2,4-thiazolidinediones (8a-e) were synthesized. These products were prepared by Knoevenagel reaction from 3'-flavone carboxaldehyde and 3-substituted 2,4-thiazolidinediones. In vitro insulinotropic activity was determined for compounds 6a-e, 7a-e, 8b and 8c.

摘要

合成了一系列新的3-苄基（对取代苄基）-5-[3'-(4H-4-氧代-1-苯并吡喃-2-基)-亚苄基]-2,4-噻唑烷二酮（8a - e）。这些产物是通过克诺文纳格尔反应由3'-黄酮醛和3-取代的2,4-噻唑烷二酮制备的。测定了化合物6a - e、7a - e、8b和8c的体外促胰岛素分泌活性。

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1
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