预防性口服维生素K的六年经验
Six years' experience of prophylactic oral vitamin K.
作者信息
Wariyar U, Hilton S, Pagan J, Tin W, Hey E
机构信息
Northumberland Health Authority, Morpeth.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2000 Jan;82(1):F64-8. doi: 10.1136/fn.82.1.f64.
Abstract
AIMS
The ability of oral vitamin K to eliminate all risk of vitamin K deficiency bleeding during the first three months of life was studied.
METHODS
Babies (n=182,000) in the north of England judged well enough to be offered milk within 12 hours of birth were given 1 mg of phytomenadione (vitamin K(1)) suspended in a medium chain triglyceride oil by mouth at delivery between 1993 and 1998. The parents of those who were breastfed were given a further three doses to give to the baby once every two weeks after discharge.
RESULTS
Four breastfed babies developed late vitamin K deficiency bleeding. In two, staff failed to follow policy guidelines, and in two there was undiagnosed alpha(1) antitrypsin deficiency. Audit suggested that 93% of breastfed babies had all four doses, as advised.
CONCLUSIONS
An oral product that parents can administer themselves would be popular if licensed, but the total dose offered may need to be more than in this study if babies with undiagnosed liver disease are to be protected.
摘要
目的
研究口服维生素K消除出生后前三个月维生素K缺乏性出血所有风险的能力。
方法
1993年至1998年期间，在英格兰北部出生后12小时内被判定状况良好可接受喂奶的婴儿（n = 182,000），在分娩时口服1毫克溶于中链甘油三酯油的植物甲萘醌（维生素K1）。母乳喂养婴儿的父母在出院后每两周给婴儿额外服用三剂。
结果
4名母乳喂养婴儿发生了迟发性维生素K缺乏性出血。其中2名是因为工作人员未遵循政策指南，另外2名是因为未诊断出的α1抗胰蛋白酶缺乏症。审核表明，93%的母乳喂养婴儿按建议服用了全部四剂。
结论
如果获得许可，一种可供父母自行给药的口服产品将会很受欢迎，但如果要保护未诊断出肝病的婴儿，提供的总剂量可能需要高于本研究中的剂量。
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