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对肿瘤抗原免疫反应的调节：抗IA同种异体抗血清对同基因肿瘤免疫的干扰。

Regulation of immune response to tumor antigen: interference with syngeneic tumor immunity by anti-IA alloantisera.

作者信息

Perry L L, Dorf M E, Benacerraf B, Greene M I

出版信息

Proc Natl Acad Sci U S A. 1979 Feb;76(2):920-4. doi: 10.1073/pnas.76.2.920.

DOI:10.1073/pnas.76.2.920
PMID:106399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC383093/
Abstract

We present evidence for a role of I-A subregion-encoded determinants in syngeneic tumor immunity. In animals rendered immune to the S1509a fibrosarcoma, daily treatment with microliter quantities of antisera directed against Kk and I-Ak determinants expressed on lymphoid cells of host origin decreased the capacity for immune tumor rejection. Absorption studies revealed that anti-I-Ak antibody activity alone was sufficient for the manifestation of this effect. Furthermore, experiments utilizing F1 hybrids showed that an antiserum that was genetically unable to interact with H-2 determinants expressed on the tumor was equally effective in inhibiting tumor immunity. Suggestive evidence that the activity of this antiserum is related to interference with the generation of effector T cell function was provided by the observation that hyperimmune animals pretreated with an anti-Kk,I-Ak antiserum were no longer capable of adoptively transferring tumor immunity to naive recipients. Thus, it is possible to regulate the secondary immune response to tumor antigens by using antisera with specificity for I-A determinants expressed on cells or possibly on factors of the host lymphoid system.

摘要

我们提供了I-A亚区编码决定簇在同基因肿瘤免疫中作用的证据。在对S1509a纤维肉瘤产生免疫的动物中，每天用微升量针对宿主来源淋巴细胞上表达的Kk和I-Ak决定簇的抗血清进行治疗，会降低免疫肿瘤排斥的能力。吸收研究表明，仅抗I-Ak抗体活性就足以表现出这种效应。此外，利用F1杂种进行的实验表明，一种在遗传上无法与肿瘤上表达的H-2决定簇相互作用的抗血清在抑制肿瘤免疫方面同样有效。通过观察发现，用抗Kk、I-Ak抗血清预处理的超免疫动物不再能够将肿瘤免疫过继转移给未免疫的受体，这为该抗血清的活性与干扰效应T细胞功能的产生有关提供了提示性证据。因此，有可能通过使用对细胞上或可能对宿主淋巴系统因子上表达的I-A决定簇具有特异性的抗血清来调节对肿瘤抗原的二次免疫反应。

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本文引用的文献

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Further evidence for the involvement of thymus-processed lymphocytes in syngeneic tumor cell cytolysis.胸腺处理的淋巴细胞参与同基因肿瘤细胞溶解的进一步证据。
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Anti-theta serum-induced supression of the cellular transfer of tumour-specific immunity to a syngeneic plasma cell tumour.抗θ血清诱导对同基因浆细胞瘤肿瘤特异性免疫细胞转移的抑制作用。
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Regulation of the immune response to tumor antigens. II. The nature of immunosuppressor cells in tumor-bearing hosts.对肿瘤抗原免疫反应的调节。II. 荷瘤宿主中免疫抑制细胞的性质。
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Antibody-dependent lymphocyte cytotoxicity in the murine sarcoma virus system: activity of IgM and IgG with specificity for MLV determined antigen(s).鼠肉瘤病毒系统中的抗体依赖性淋巴细胞细胞毒性：对MLV确定抗原具有特异性的IgM和IgG的活性
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