抑制性T细胞抗原受体上独特型与I-J决定簇的功能关联。
Functional association of idiotypic and I-J determinants on the antigen receptor of suppressor T cells.
作者信息
Okuda K, Minami M, Ju S T, Dorf M E
出版信息
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4557-61. doi: 10.1073/pnas.78.7.4557.
Abstract
The serological characteristics of the antigen receptor on 4-hydroxy-3-nitrophenylacetyl (NP) specific suppressor T cell hybridomas were analyzed. Three T-cell hybrids could be lysed with anti-idiotype and complement. The reactivity pattern observed from a panel of anti-idiotypic reagents indicated that NPb determinants were detected on all three hybrid lines. NP conjugates with bovine serum albumin or caproic acid specifically inhibited the complement-mediated lysis of these cells by both anti-NPb idiotype and anti-I-J antisera. These hapten conjugates failed to block lysis by anti-Thy 1 or anti-H-2K antisera on the same target cell populations. The data indicate that both I-J and Igh variable region gene products are intimately involved in the recognition of antigen by suppressor T cells. Finally, the suppressor cell hybrids produce soluble factors that mediate antigen-specific suppression. The characteristics of the cells and their factors indicate that the hybrids correspond to the Tsi or first-order suppressor cells in the suppressor cell pathway.
摘要
分析了4-羟基-3-硝基苯乙酰（NP）特异性抑制性T细胞杂交瘤上抗原受体的血清学特征。三种T细胞杂交瘤可被抗独特型抗体和补体裂解。从一组抗独特型试剂观察到的反应模式表明，在所有三个杂交瘤系上均检测到NPb决定簇。NP与牛血清白蛋白或己酸的缀合物可特异性抑制抗NPb独特型抗体和抗I-J抗血清对这些细胞的补体介导的裂解。这些半抗原缀合物不能阻断同一靶细胞群体上抗Thy 1或抗H-2K抗血清的裂解作用。数据表明，I-J和Igh可变区基因产物均密切参与抑制性T细胞对抗原的识别。最后，抑制性细胞杂交瘤产生介导抗原特异性抑制的可溶性因子。这些细胞及其因子的特征表明，杂交瘤对应于抑制性细胞途径中的Tsi或一级抑制性细胞。
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