Hernandez L L, Appel J B
Psychopharmacology (Berl). 1979 Jan 31;60(2):125-30. doi: 10.1007/BF00432282.
Male albino rats were trained to detect either a pure tone or a weak footshock embedded in white noise by utilizing a discrete-trial two-choice, successive discrimination procedure. The effects of morphine, chlorpromazine (CPZ), and lysergic acid diethylamide (LSD) were then analyzed on several measures of performance. Morphine (2.5--10 mg/kg) produced a nonspecific decrease in accuracy of discrimination on trials when the stimulus was presented as well as on trials when no stimulus occurred. Morphine was also followed by dose-dependent decreased in speed to initiate trials and by increases in intersubject variability. CPZ (1.0--4.0 mg/kg) caused a decrease in accuracy only on no-stimulus trials and, like morphine decreased speed to initiate trials. LSD (0.04--0.16 mg/kg/ decreased overall accuracy in a nonspecific manner (i.e., when shock and tone discriminations were considered together) and decreased speed by producing periods of nonresponding.
通过使用离散试验二选一连续辨别程序，训练雄性白化大鼠检测嵌入白噪声中的纯音或弱电击。然后分析了吗啡、氯丙嗪（CPZ）和麦角酸二乙酰胺（LSD）对几种行为表现指标的影响。吗啡（2.5 - 10毫克/千克）在呈现刺激的试验以及无刺激试验中，都会导致辨别准确性出现非特异性下降。吗啡还会使开始试验的速度出现剂量依赖性降低，并使个体间变异性增加。CPZ（1.0 - 4.0毫克/千克）仅在无刺激试验中导致准确性下降，并且与吗啡一样，会降低开始试验的速度。LSD（0.04 - 0.16毫克/千克）以非特异性方式降低整体准确性（即，将电击和音调辨别一起考虑时），并通过产生无反应期降低速度。
