Kolle G, Georgas K, Holmes G P, Little M H, Yamada T
Centre for Molecular and Cellular Biology, The University of Queensland, Brisbane, Australia.
Mech Dev. 2000 Feb;90(2):181-93. doi: 10.1016/s0925-4773(99)00248-8.
Development of the vertebrate central nervous system is thought to be controlled by intricate cell-cell interactions and spatio-temporally regulated gene expressions. The details of these processes are still not fully understood. We have isolated a novel vertebrate gene, CRIM1/Crim1, in human and mouse. Human CRIM1 maps to chromosome 2p21 close to the Spastic Paraplegia 4 locus. Crim1 is expressed in the notochord, somites, floor plate, early motor neurons and interneuron subpopulations within the developing spinal cord. CRIM1 appears to be evolutionarily conserved and encodes a putative transmembrane protein containing an IGF-binding protein motif and multiple cysteine-rich repeats similar to those in the BMP-associating chordin and sog proteins. Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding.
脊椎动物中枢神经系统的发育被认为受复杂的细胞间相互作用和时空调节的基因表达所控制。这些过程的细节仍未完全了解。我们在人和小鼠中分离出了一个新的脊椎动物基因CRIM1/Crim1。人类CRIM1定位于2号染色体p21，靠近痉挛性截瘫4位点。Crim1在发育中的脊髓的脊索、体节、底板、早期运动神经元和中间神经元亚群中表达。CRIM1似乎在进化上是保守的，编码一种假定的跨膜蛋白，该蛋白含有一个胰岛素样生长因子结合蛋白基序和多个富含半胱氨酸的重复序列，类似于与骨形态发生蛋白相关的脊索蛋白和短臀蛋白中的重复序列。我们的结果表明CRIM1/Crim1可能通过生长因子结合在中枢神经系统发育中发挥作用。
