Bacopoulos N G, Bize I, Levine J, Van Orden L S
Psychopharmacology (Berl). 1979 Jan 31;60(2):195-201. doi: 10.1007/BF00432293.
The effects of ethanol on locomotor activity and rotarod performance were measured in the rat. Apomorphine (4 mg/kg s.c.) antagonized and pimozide (0.75 - 1.50 mg/kg s.c.) enhanced the effects of a 2 g/kg dose of ethanol on rotarod performance. No such interaction was seen with pentobarbital, 25 mg/kg, a dose sufficiency to produce an equivalent motor performance deficit. Animals with 6-hydroxydopamine lesions of the substantia nigra were more sensitive to the ethanol-induced impairment of rotarod performance and suppression of locomotor activity than shamoperated controls. The pattern of dopamine depletion in lesioned animals indicated a degree of selectivity of the lesion for the nigrostriatal pathway. The results are compatible with the hypothesis that ethanol interferes with dopaminergic transmission, and that such an interference may be involved in the behavioral effects of ethanol.
在大鼠中测量了乙醇对运动活性和转棒试验表现的影响。阿扑吗啡（4毫克/千克，皮下注射）拮抗，而匹莫齐特（0.75 - 1.50毫克/千克，皮下注射）增强了2克/千克剂量乙醇对转棒试验表现的影响。对于戊巴比妥（25毫克/千克，足以产生等效运动表现缺陷的剂量），未观察到这种相互作用。与假手术对照组相比，黑质6-羟基多巴胺损伤的动物对乙醇诱导的转棒试验表现受损和运动活性抑制更为敏感。损伤动物中多巴胺耗竭的模式表明该损伤对黑质纹状体通路具有一定程度的选择性。这些结果与乙醇干扰多巴胺能传递的假说相符，并且这种干扰可能参与了乙醇的行为效应。
