中枢多巴胺能活性影响大鼠的运动能力。
Central dopaminergic activity influences rats ability to exercise.
作者信息
Heyes M P, Garnett E S, Coates G
出版信息
Life Sci. 1985 Feb 18;36(7):671-7. doi: 10.1016/0024-3205(85)90172-9.
PMID:3918227
Abstract
Rats were run to exhaustion on a motor driven treadmill. Apomorphine given to intact rats prolonged the time to exhaustion. Apomorphine given to 6-hydroxydopamine lesioned rats also prolonged the time to exhaustion. Intracerebroventricular 6-hydroxydopamine alone reduced the time to exhaustion. Clonidine given to these animals had no effect. We suggest that central dopaminergic activity influences rats ability to exercise.
摘要
将大鼠放在电动跑步机上跑至疲惫。给完整的大鼠注射阿扑吗啡可延长其疲惫时间。给6-羟基多巴胺损伤的大鼠注射阿扑吗啡也可延长其疲惫时间。单独给予脑室内6-羟基多巴胺会缩短疲惫时间。给这些动物注射可乐定则没有效果。我们认为中枢多巴胺能活性会影响大鼠的运动能力。
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