急性白血病诱导治疗期间多育赛多孢菌所致致命性播散性感染：1例报告及文献复习
Fatal disseminated infection by Scedosporium prolificans during induction therapy for acute leukemia: a case report and literature review.
作者信息
Westerman D A, Speed B R, Prince H M
机构信息
Peter MacCallum Cancer Institute, East Melbourne, Vic., Australia.
出版信息
Pathology. 1999 Nov;31(4):393-4. doi: 10.1080/003130299104783.
PMID:10643012
Abstract
We report a case of fatal disseminated fungal infection by Scedosporium prolificans which occurred in a patient with acute leukemia during induction chemotherapy. Rapid clinical deterioration despite high-dose empirical amphotericin B highlights both the pathogenicity of this fungus in immunocompromised hosts and its resistance to standard antifungal therapy.
摘要
我们报告了一例由多育赛多孢菌引起的致命播散性真菌感染病例，该病例发生在一名急性白血病患者的诱导化疗期间。尽管给予了高剂量经验性两性霉素B治疗，但患者临床病情仍迅速恶化，这凸显了这种真菌在免疫功能低下宿主中的致病性及其对标准抗真菌治疗的耐药性。
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