Gamble J L
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Am J Physiol. 1999 Dec;277(6 Pt 2):S136-9. doi: 10.1152/advances.1999.277.6.S136.
Buffering of "metabolic" acid in tissues other than blood correlates closely with a change in extracellular bicarbonate concentration rather than with a change in extracellular pH. Of particular importance is the evidence for an absence of relation to change in pH. Questions are raised with respect to buffering mechanism, but simplification is offered for diagnosis. A clearer focus can be given to the guidepost changes in PCO2 and bicarbonate concentration. Basic relationships of buffering in the whole body are reviewed, and a modified diagnostic rationale is offered, based on a two-rather than a three-dimensional analysis.
除血液外的其他组织中“代谢性”酸的缓冲与细胞外碳酸氢盐浓度的变化密切相关，而不是与细胞外pH值的变化相关。特别重要的是不存在与pH值变化相关的证据。这引发了关于缓冲机制的问题，但为诊断提供了简化方法。可以更明确地关注PCO2和碳酸氢盐浓度的指示性变化。回顾了全身缓冲的基本关系，并基于二维而非三维分析提供了一种改进的诊断原理。
