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1
Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen.在移植了非进展者外周血单个核细胞的SCID-Hu小鼠中，对人免疫缺陷病毒攻击的复制抗性由CD8(+) T细胞介导，并与对p24抗原的增殖反应相关。
J Virol. 2000 Feb;74(4):2023-8. doi: 10.1128/jvi.74.4.2023-2028.2000.
2
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3
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6
Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies.自体CD8 + T细胞对静息CD4 + T细胞库中HIV复制的抑制作用：对治疗策略发展的启示
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HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors.HIV特异性CD8 + T细胞增殖与穿孔素表达相关联，并在疾病非进展者中得以维持。
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Selective regulation of human immunodeficiency virus-infected CD4(+) lymphocytes by a synthetic immunomodulator leads to potent virus suppression in vitro and in hu-PBL-SCID mice.一种合成免疫调节剂对人类免疫缺陷病毒感染的CD4(+)淋巴细胞的选择性调节导致体外和人外周血淋巴细胞-严重联合免疫缺陷小鼠体内有效的病毒抑制。
J Virol. 2001 Aug;75(15):6941-52. doi: 10.1128/JVI.75.15.6941-6952.2001.
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Asian Pac J Allergy Immunol. 2004 Mar;22(1):39-48.

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本文引用的文献

1
Lymphoproliferative response to HIV type 1 p24 in long-term survivors of HIV type 1 infection is predictive of persistent AIDS-free infection.
AIDS Res Hum Retroviruses. 1999 Jul 20;15(11):973-81. doi: 10.1089/088922299310485.
2
Broad, intense anti-human immunodeficiency virus (HIV) ex vivo CD8(+) responses in HIV type 1-infected patients: comparison with anti-Epstein-Barr virus responses and changes during antiretroviral therapy.1型人类免疫缺陷病毒（HIV）感染患者体内广泛、强烈的抗HIV离体CD8(+)反应：与抗爱泼斯坦-巴尔病毒反应的比较及抗逆转录病毒治疗期间的变化
J Virol. 1999 Sep;73(9):7108-16. doi: 10.1128/JVI.73.9.7108-7116.1999.
3
Plasma human immunodeficiency virus RNA below 40 Copies/mL is rare in untreated persons even in the first years of infection.血浆中人类免疫缺陷病毒RNA低于40拷贝/毫升在未经治疗的人群中很少见，即使在感染的最初几年也是如此。
J Infect Dis. 1999 Aug;180(2):526-9. doi: 10.1086/314906.
4
Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients.黑色素瘤患者中肿瘤相关抗原特异性循环T细胞的特征分析。
Nat Med. 1999 Jun;5(6):677-85. doi: 10.1038/9525.
5
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.在感染猿猴免疫缺陷病毒的猕猴中，CD8(+) T细胞耗竭后血浆病毒血症急剧上升。
J Exp Med. 1999 Mar 15;189(6):991-8. doi: 10.1084/jem.189.6.991.
6
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.CD8 + 淋巴细胞对猿猴免疫缺陷病毒感染中病毒血症的控制。
Science. 1999 Feb 5;283(5403):857-60. doi: 10.1126/science.283.5403.857.
7
Virological and immunological features of long-term human immunodeficiency virus-infected individuals who have remained asymptomatic compared with those who have progressed to acquired immunodeficiency syndrome.与已进展为获得性免疫缺陷综合征的个体相比，长期无症状感染人类免疫缺陷病毒个体的病毒学和免疫学特征。
Blood. 1998 Nov 1;92(9):3105-14.
8
Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques.在恒河猴的初次感染期间，给予抗CD8单克隆抗体可干扰嵌合猿猴/人类免疫缺陷病毒的清除。
J Virol. 1998 Jan;72(1):164-9. doi: 10.1128/JVI.72.1.164-169.1998.
9
Host factors in the pathogenesis of HIV disease.HIV疾病发病机制中的宿主因素。
Immunol Rev. 1997 Oct;159:31-48. doi: 10.1111/j.1600-065x.1997.tb01005.x.
10
CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity.CD4+ T细胞辅助会损害由自身抗原交叉呈递诱导的CD8+ T细胞清除，并有利于自身免疫。
J Exp Med. 1997 Dec 15;186(12):2057-62. doi: 10.1084/jem.186.12.2057.

在移植了非进展者外周血单个核细胞的SCID-Hu小鼠中，对人免疫缺陷病毒攻击的复制抗性由CD8(+) T细胞介导，并与对p24抗原的增殖反应相关。

Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen.

作者信息

de Quiros J C, Shupert W L, McNeil A C, Gea-Banacloche J C, Flanigan M, Savage A, Martino L, Weiskopf E E, Imamichi H, Zhang Y M, Adelsburger J, Stevens R, Murphy P M, Zimmerman P A, Hallahan C W, Davey R T, Connors M

机构信息

Servicio de Medicina Interna 1, Clinica Puerta de Hierro, Universidad Autonoma de Madrid, and Servicio de Microbiologia, Hospital General Gregorio Maranon, Madrid, Spain.

出版信息

J Virol. 2000 Feb;74(4):2023-8. doi: 10.1128/jvi.74.4.2023-2028.2000.

DOI:10.1128/jvi.74.4.2023-2028.2000
PMID:10644376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC111681/
Abstract

High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8(+) T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.

摘要

在移植了四名长期不进展者（LTNP）外周血单个核细胞的动物中，观察到对1型人类免疫缺陷病毒SF162攻击具有高度抗性。体内CD8(+) T细胞耗竭可消除这种抗性，并且仅在对p24有增殖反应的LTNP中观察到这种抗性。在一部分不进展者中，CD8(+) T细胞介导对攻击病毒的限制，并且这种反应与对p24抗原的强烈增殖反应相关。