Xu R, Cai J, Xu T, Zhou W, Ying B, Deng K, Zhao S, Li C
State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai, 200433, People's Republic of China.
Genomics. 1999 Dec 15;62(3):537-9. doi: 10.1006/geno.1999.6029.
Members of the ADAM family (type I integral membrane protein with a disintegrin and metalloprotease domain) have been implicated in many important biological processes involving cell-cell and cell-matrix interactions, such as fertilization and myoblast fusion. We report here the cDNA sequence of a novel human ADAM gene (ADAM29) that contains a putative fusion peptide. Northern blot analysis revealed that the mRNA of ADAM29 is highly expressed in the testis. By radiation hybrid panel mapping, the ADAM29 gene was assigned to human chromosome 4q34.2-qter.
ADAM家族成员（具有解整合素和金属蛋白酶结构域的I型整合膜蛋白）参与了许多涉及细胞间和细胞与基质相互作用的重要生物学过程，如受精和成肌细胞融合。我们在此报告一种新型人类ADAM基因（ADAM29）的cDNA序列，该基因含有一个假定的融合肽。Northern印迹分析显示，ADAM29的mRNA在睾丸中高度表达。通过辐射杂种板定位，将ADAM29基因定位于人类染色体4q34.2 - qter。
