Burguera B, Proctor D, Dietz N, Guo Z, Joyner M, Jensen M D
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E113-7. doi: 10.1152/ajpendo.2000.278.1.E113.
We previously reported that epinephrine stimulates leg free fatty acid (FFA) release in men but not in women. The present studies were conducted to determine whether the same is true during exercise. Six men and six women bicycled for 90 min at 45% of peak O(2) consumption, during which time systemic and leg FFA kinetics ([9, 10-(3)H]palmitate) were measured. The catecholamine and hormonal responses to exercise were not different in men and women. The baseline systemic and leg palmitate release was 94 +/- 15 vs. 114 +/- 5 micromol/min and 16 +/- 2 and 20 +/- 3 micromol/min, respectively, in men and women [P = nonsignificant (NS)]. Systemic and leg palmitate release increased (both P < 0.001) to 251 +/- 18 vs. 212 +/- 16 micromol/min and 73 +/- 19 vs. 80 +/- 12 micromol/min in men and women, respectively, during the last 30 min of exercise (P = NS, men vs. women). We conclude that the systemic and leg adipose tissue lipolytic response to exercise is not different in nonobese men and women.
我们之前报道过，肾上腺素可刺激男性腿部游离脂肪酸（FFA）释放，但对女性无此作用。本研究旨在确定运动期间是否也是如此。6名男性和6名女性以最大耗氧量（O₂）的45%进行90分钟的骑行，在此期间测量全身和腿部FFA动力学（[9,10-(³)H]棕榈酸）。男性和女性运动时儿茶酚胺和激素反应无差异。男性和女性基线时全身和腿部棕榈酸释放量分别为94±15与114±5微摩尔/分钟以及16±2与20±3微摩尔/分钟[P=无显著性差异（NS）]。在运动的最后30分钟，男性和女性全身和腿部棕榈酸释放量均增加（P均<0.001），分别增至251±18与212±16微摩尔/分钟以及73±19与80±12微摩尔/分钟（男性与女性相比，P=NS）。我们得出结论，非肥胖男性和女性运动时全身和腿部脂肪组织的脂解反应无差异。
