Matsubara O, Takemura T
Bull Tokyo Med Dent Univ. 1975 Sep;22(3):193-205.
The renal microvasculature was examined stereoscopically after intraarterial injection of silicone rubber. Specimens studied were: 29 cases of normal kidney, 4 cases of sclerotic kidney, 10 cases of acute renal failure, and 10 cases of chronic renal failure from the final stage of chronic glomerulonephritis, malignant nephrosclerosis, diabetic nephropathy, and cortical necrosis. The following were common evidences for chronic renal failure: much reduction and wide deficiencies of filling in the cortex, increased filling of vasa recta, narrowing and spiralling of interlobular arteries and cortical afferent arterioles, appearance of giant glomeruli, rarefaction of the peritubular capillary plexus, and relative preservation of glomeruli in the juxtamedullary zone and vasa recta in the medulla may be the major pathway, after the interlobular arteries and afferent arterioles in the subcapsular cortex are destroyed, and these vascular architectural changes may be intimately related to the pathophysiology of chronic renal failure.
在动脉内注射硅橡胶后，对肾微血管系统进行了立体显微镜检查。研究的标本包括：29例正常肾脏、4例硬化性肾脏、10例急性肾衰竭以及10例来自慢性肾小球肾炎终末期、恶性肾硬化、糖尿病肾病和皮质坏死的慢性肾衰竭病例。以下是慢性肾衰竭的常见表现：皮质内充盈大量减少且广泛缺失、直小血管充盈增加、小叶间动脉和皮质传入小动脉变窄并呈螺旋状、出现巨大肾小球、肾小管周围毛细血管丛稀疏，而近髓质区肾小球和髓质直小血管相对保留可能是主要途径，在肾包膜下皮质的小叶间动脉和传入小动脉被破坏后，这些血管结构变化可能与慢性肾衰竭的病理生理学密切相关。
