Kan'shina N F
Arkh Patol. 1977;39(9):43-9.
The autopsy material was used for histological and histochemical study of lesions in tubules of the kidneys in chronic glomerulonephritis in comparison with those in acute renal insuffuciency (ARI) of various etiologies. In addition to the phenomena of intracellular regeneration in tubules of the functioning nephrons with formations of nephromas and tubule atrophy in the zone of glomerular sclerosis, some observations showed signs of insufficiency of cortical circulation. They were manifested in dystrophy of the proximal segment epithelium. Dystrophic changes are followed by regeneration which occurs at different times and runs an irregular course. Changes in the tubules are similar to those observed in the oligo-anuria stage of ARI. When cortical circulation is not compensated, paresis and collateral insufficiency develop. Small cortical necroses may be formed. All these changes, when they occur in extracapillary proliferation, may be manifested by the clinical symptocomplex of acute renal insufficiency.
尸检材料用于对慢性肾小球肾炎患者肾小管病变进行组织学和组织化学研究，并与各种病因引起的急性肾功能不全（ARI）患者的肾小管病变进行比较。除了在功能肾单位的肾小管中出现细胞内再生现象，伴有肾瘤形成以及肾小球硬化区域的肾小管萎缩外，一些观察结果还显示出皮质循环不足的迹象。其表现为近端段上皮营养不良。营养不良性变化之后会发生再生，再生在不同时间出现且过程不规则。肾小管的变化与ARI少尿 - 无尿期观察到的变化相似。当皮质循环得不到代偿时，会出现轻瘫和侧支循环不足。可能会形成小的皮质坏死。当所有这些变化发生在毛细血管外增生时，可能会表现为急性肾功能不全的临床症状复合体。
