Sudhakar K, Sujatha M, Rao V B, Jyothy A, Reddy P P
Institute of Genetics, Osmania University, Hyderabad.
J Indian Med Assoc. 1999 Jun;97(6):211-3.
Essential hypertension is an arbitrarily defined disorder to which both genetic and environmental factors contribute. Magnesium and its interactions with other cations may play an important role in the pathogenesis of essential hypertension. Various studies have been carried out on the levels of serum and erythrocyte magnesium in hypertensives and the results are controversial and there is no systematic study in Indian population. In the present study serum and erythrocyte magnesium levels in 86 hypertensives and their 77 first degree relatives as well as in sex and age matched controls were studied. Serum and erythrocyte magnesium levels showed a significant decrease both in the hypertensives and their first degree relatives (p < 0.01). The significantly decreased levels of magnesium in the first degree relatives suggest genetic basis of essential hypertension and may be used as marker to identify those at risk.
原发性高血压是一种由遗传和环境因素共同导致的、定义较为随意的疾病。镁及其与其他阳离子的相互作用可能在原发性高血压的发病机制中发挥重要作用。针对高血压患者血清和红细胞镁水平开展了多项研究，结果存在争议，并且在印度人群中尚无系统性研究。在本研究中，对86例高血压患者及其77名一级亲属以及性别和年龄匹配的对照组的血清和红细胞镁水平进行了研究。高血压患者及其一级亲属的血清和红细胞镁水平均显著降低（p < 0.01）。一级亲属中镁水平显著降低表明原发性高血压存在遗传基础，并且可作为识别高危人群的标志物。
