Sasaki S, Oshima T, Matsuura H, Ozono R, Higashi Y, Sasaki N, Matsumoto T, Nakano Y, Ueda A, Yoshimizu A, Kurisu S, Kambe M, Kajiyama G
First Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan 734-8551.
Clin Sci (Lond). 2000 Feb;98(2):175-81.
To investigate magnesium status in patients with cardiovascular diseases and in those presenting high factors for these diseases, we measured the concentrations of serum total Mg, serum ionized Mg and intra-erythrocyte Mg. Mg is an important cofactor for many enzymes, especially those involved in phosphate transfer reactions. Mg deficiency has been shown to be associated with fatal cardiovascular diseases, as well as with risk factors for these diseases. Only measurement of the serum concentration of total Mg is routinely available, but ionized Mg is the physiologically active component. Furthermore, most of the body's Mg is present in the intracellular space. Subjects included patients with ischaemic heart disease (n=80), cardiac arrhythmia (n=60), diabetes mellitus (n=36), essential hypertension (n=194) and hypercholesterolaemia (n=60). The same measurements were made in healthy controls (30 men and 26 women; mean age 58+/-11 years). The serum ionized Mg concentration was measured with a selective ion electrode. The intra-erythrocyte Mg concentration was measured by atomic absorption. No gender difference was found for any Mg parameter, nor was age related to any Mg parameter. The serum albumin concentration was positively correlated only with the serum total Mg concentration. Although the serum total Mg concentration was similar in all groups, patients with diabetes mellitus and arrhythmia had lower serum levels of ionized Mg. Patients with essential hypertension exhibited higher intra-erythrocyte Mg concentrations than the healthy controls. Thus the measurement of serum total Mg concentration may obscure the presence of extracellular Mg deficiency in patients with arrhythmia and diabetes mellitus. Furthermore, the intracellular accumulation of Mg does not support the hypothesis of Mg deficiency in patients with essential hypertension.
为了调查心血管疾病患者以及具有这些疾病高风险因素人群的镁状态，我们测量了血清总镁、血清离子化镁和红细胞内镁的浓度。镁是许多酶的重要辅助因子，尤其是那些参与磷酸转移反应的酶。镁缺乏已被证明与致命性心血管疾病以及这些疾病的风险因素有关。目前常规仅能测量血清总镁浓度，但离子化镁才是生理活性成分。此外，人体大部分的镁存在于细胞内空间。研究对象包括缺血性心脏病患者（n = 80）、心律失常患者（n = 60）、糖尿病患者（n = 36）、原发性高血压患者（n = 194）和高胆固醇血症患者（n = 60）。对健康对照组（30名男性和26名女性；平均年龄58±11岁）进行了相同的测量。血清离子化镁浓度用选择性离子电极测量。红细胞内镁浓度用原子吸收法测量。未发现任何镁参数存在性别差异，也未发现年龄与任何镁参数有关。血清白蛋白浓度仅与血清总镁浓度呈正相关。尽管所有组的血清总镁浓度相似，但糖尿病患者和心律失常患者的血清离子化镁水平较低。原发性高血压患者的红细胞内镁浓度高于健康对照组。因此，测量血清总镁浓度可能会掩盖心律失常和糖尿病患者细胞外镁缺乏的情况。此外，原发性高血压患者细胞内镁的积累并不支持其镁缺乏的假说。
