3CaO·P2O5-CaO·SiO2-CaO·MgO·2SiO2体系玻璃及玻璃陶瓷的体外生物活性
In vitro bioactivity of glass and glass-ceramics of the 3CaO x P2O5-CaO x SiO2-CaO x MgO x 2SiO2 system.
作者信息
Salinas A J, Román J, Vallet-Regí M, Oliveira J M, Correia R N, Fernandes M H
机构信息
Departmento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
出版信息
Biomaterials. 2000 Feb;21(3):251-7. doi: 10.1016/s0142-9612(99)00150-7.
A glass of nominal composition (wt%) 40.0 CaO-34.5 SiO2-16.5 P2O5-8.5 MgO-0.5 CaF2 has been obtained (G13). The glass showed in vitro bioactivity evidenced by the formation on its surface of a calcium phosphate-rich layer when soaked in a solution with ionic composition analogous to human plasma. By thermal treatments of G13, a glass-ceramic (GC13) containing apatite, diopside, althausite and akermanite as crystalline phases was developed. GC13 as-made did not show in vitro bioactivity. However, after chemical treatment of GC13 with 1 M HCl (GC13-HCl), the in vitro studies showed the formation of an apatite-like layer covering certain areas of the material surface. The influence of both chemical and morphological factors on the in vitro bioactivity has been studied.
已制备出一种标称成分（重量百分比）为40.0 CaO - 34.5 SiO₂ - 16.5 P₂O₅ - 8.5 MgO - 0.5 CaF₂的玻璃（G13）。当将该玻璃浸泡在离子组成类似于人体血浆的溶液中时，其表面形成富含磷酸钙的层，这证明了该玻璃具有体外生物活性。通过对G13进行热处理，开发出了一种含有磷灰石、透辉石、钙镁橄榄石和钙镁黄长石作为结晶相的玻璃陶瓷（GC13）。刚制备的GC13未表现出体外生物活性。然而，在用1 M HCl对GC13进行化学处理（GC13 - HCl）后，体外研究表明在材料表面的某些区域形成了类似磷灰石的层。已经研究了化学和形态因素对体外生物活性的影响。
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