Oliveira J M, Correia R N, Fernandes M H
Department of Ceramics and Glass Engineering, University of Avelro, Portugal.
Biomaterials. 1995 Jul;16(11):849-54. doi: 10.1016/0142-9612(95)94146-c.
A glass of nominal composition (wt%) 17.25 MgO-52.75 3CaO.P2O5-30 SiO2 and a glass-ceramic obtained from it showed surface modifications when immersed in an acellular medium having a composition similar to that of human blood plasma. A (Ca, P)-rich layer, with an approximate Ca/P atomic ratio of 1.7, identified as hydroxyapatite, developed on both samples. The precipitated film on the glassy sample was weakly bonded, whereas that formed on the glass-ceramic was strongly adherent. The apatite precipitated during the in vitro tests on both samples grew as a needle-like structure with crystals about 150-200 nm long and 50-70 nm thick, as measured on specimens soaked for 1 month in the simulated body fluid (SBF). The presence of calcium and phosphate ions in the SBF contributed to the precipitation of the (Ca, P)-rich layers on both specimens.
一种标称成分（重量百分比）为17.25%氧化镁-52.75% 3CaO·P₂O₅-30%二氧化硅的玻璃以及由其制成的微晶玻璃，当浸入一种成分与人血浆相似的无细胞培养基中时，会出现表面改性。在两个样品上都形成了一层富含（钙，磷）的层，其钙/磷原子比约为1.7，被鉴定为羟基磷灰石。玻璃样品上沉淀的薄膜结合较弱，而微晶玻璃上形成的薄膜则牢固附着。在体外测试中，两个样品上沉淀的磷灰石生长为针状结构，在模拟体液（SBF）中浸泡1个月的标本上测量，晶体长度约为150-200纳米，厚度为50-70纳米。SBF中钙和磷酸根离子的存在促成了两个标本上富含（钙，磷）层的沉淀。
