Basile A, Giordano S, López-Sáez J A, Cobianchi R C
Dipartimento di Biologia Vegetale, Università Federico II, Naples, Italy.
Phytochemistry. 1999 Dec;52(8):1479-82. doi: 10.1016/s0031-9422(99)00286-1.
Seven pure flavonoids were isolated and identified from five moss species. The flavonoids were the flavones apigenin, apigenin-7-O-triglycoside, lucenin-2, luteolin-7-O-neohesperidoside, saponarine and vitexin; and the biflavonoid bartramiaflavone. Some of these flavonoids were shown to have pronounced antibacterial effects against Enterobacter cloaceae, E. aerogenes and Pseudomonas aeruginosa (minimal bacteriostatic concentration MIC in the range of 4-2048 micrograms/ml). Because of their antibacterial spectrum mainly active against Gram negative bacterial strains, responsible for severe opportunistic infections and resistant to common antibacterial therapy, these flavonoids may be important tools in antibacterial strategies.
从五种苔藓植物中分离并鉴定出了七种纯黄酮类化合物。这些黄酮类化合物包括黄酮类的芹菜素、芹菜素 - 7 - O - 三糖苷、卢森宁 - 2、木犀草素 - 7 - O - 新橙皮糖苷、皂草苷和牡荆素；以及双黄酮类的扁枝石松黄酮。其中一些黄酮类化合物对阴沟肠杆菌、产气肠杆菌和铜绿假单胞菌显示出显著的抗菌作用（最小抑菌浓度MIC在4 - 2048微克/毫升范围内）。由于它们的抗菌谱主要对革兰氏阴性菌菌株有活性，这些菌株会导致严重的机会性感染且对常见抗菌治疗有抗性，因此这些黄酮类化合物可能是抗菌策略中的重要工具。
