Vacchio M S, Jiang S P
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Crit Rev Immunol. 1999;19(5-6):461-80.
In this article, we discuss recent findings that describe how maternal T cells respond upon encountering fetal antigens. Many earlier studies have characterized changes in the maternal T-cell repertoire of both humans and mice, yet it has been difficult to understand the significance of these findings since there has been no way to decipher if the alterations were the result of encounters with fetal antigens or were nonspecific changes related to pregnancy itself. Now, in the mouse, the availability of TCR transgenic mice and other technological advances allow direct visualization of the fate of maternal T cells that are reactive to the fetus and provide a means to probe the mechanisms by which tolerance to the fetus is maintained. This article focuses on how the fetus more closely resembles "developmental self' than a true allograft and how the study of maternal T-cell interactions with fetally derived antigens can be useful as a model for the study of peripheral T-cell tolerance.
在本文中，我们讨论了近期的研究发现，这些发现描述了母体T细胞在遇到胎儿抗原时的反应。许多早期研究已经对人类和小鼠母体T细胞库的变化进行了特征描述，但由于无法解读这些变化是与胎儿抗原接触的结果，还是与妊娠本身相关的非特异性变化，因此很难理解这些发现的意义。现在，在小鼠中，TCR转基因小鼠的出现和其他技术进步使得能够直接观察对胎儿有反应的母体T细胞的命运，并提供了一种探究维持对胎儿耐受性机制的方法。本文重点关注胎儿如何比真正的同种异体移植物更类似于“发育中的自身”，以及研究母体T细胞与胎儿来源抗原的相互作用如何作为研究外周T细胞耐受性的模型。
