Lotufo P A, Chae C U, Ajani U A, Hennekens C H, Manson J E
Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Mass 02215-1204, USA.
Arch Intern Med. 2000 Jan 24;160(2):165-71. doi: 10.1001/archinte.160.2.165.
To examine the association between male pattern baldness and the risk of coronary heart disease (CHD) events.
DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study among 22,071 US male physicians aged 40 to 84 years enrolled in the Physicians' Health Study. Of these, 19,112 were free of CHD at baseline and completed a questionnaire at the 11-year follow-up concerning their pattern of hair loss at age 45 years. Response options included no hair loss, frontal baldness only, or frontal baldness with mild, moderate, or severe vertex baldness.
Coronary heart disease events defined as nonfatal myocardial infarction (MI), angina pectoris, and/or coronary revascularization.
During 11 years of follow-up, we documented 1446 CHD events in this cohort. Compared with men with no hair loss, those with frontal baldness had an age-adjusted relative risk (RR) of CHD of 1.09 (95% confidence interval [CI], 0.94-1.25), while those with mild, moderate, or severe vertex baldness had RRs of 1.23 (95% CI, 1.05-1.43), 1.32 (95% CI, 1.10-1.59), and 1.36 (95% CI, 1.11-1.67), respectively (P for trend, <.001). Multivariate adjustment for age, parental history of MI, height, body mass index (weight in kilograms divided by the square of the height in meters as a continuous variable), smoking, history of hypertension, diabetes, high cholesterol level, physical activity, and alcohol intake did not materially alter these associations. Results were similar when nonfatal MI, angina, and coronary revascularization were examined separately, and when events were analyzed among men older and younger than 55 years at baseline. Vertex baldness was more strongly associated with CHD risk among men with hypertension (multivariate RR, 1.79; 95% CI, 1.31-2.44) or high cholesterol levels (multivariate RR, 2.78; 95% CI, 1.09-7.12).
Vertex pattern baldness appears to be a marker for increased risk of CHD events, especially among men with hypertension or high cholesterol levels.
研究男性型秃发与冠心病（CHD）事件风险之间的关联。
设计、背景和参与者：对参加医师健康研究的22071名年龄在40至84岁之间的美国男性医师进行回顾性队列研究。其中，19112人在基线时无冠心病，并在11年随访时完成了一份关于其45岁时脱发模式的问卷。回答选项包括无脱发、仅前额秃发或前额秃发伴有轻度、中度或重度头顶秃发。
冠心病事件定义为非致命性心肌梗死（MI）、心绞痛和/或冠状动脉血运重建。
在11年的随访期间，我们在该队列中记录了1446例冠心病事件。与无脱发的男性相比，前额秃发男性的冠心病年龄调整相对风险（RR）为1.09（95%置信区间[CI]，0.94 - 1.25），而轻度、中度或重度头顶秃发男性的RR分别为1.23（95%CI，1.05 - 1.43）、1.32（95%CI，1.10 - 1.59）和1.36（95%CI，1.11 - 1.67）（趋势P值，<.001）。对年龄、心肌梗死家族史、身高、体重指数（体重以千克为单位除以身高以米为单位的平方作为连续变量）、吸烟、高血压病史、糖尿病、高胆固醇水平、身体活动和饮酒情况进行多变量调整后，这些关联没有实质性改变。当分别检查非致命性心肌梗死、心绞痛和冠状动脉血运重建，以及在基线时年龄大于和小于55岁的男性中分析事件时，结果相似。头顶秃发与高血压男性（多变量RR，1.79；95%CI，1.31 - 2.44）或高胆固醇水平男性（多变量RR，2.78；95%CI，1.09 - 7.12）的冠心病风险关联更强。
头顶秃发似乎是冠心病事件风险增加的一个标志物，尤其是在高血压或高胆固醇水平的男性中。
