Danesh-Shakiba Mohammad, Poorolajal Jalal, Alirezaei Pedram
School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Clin Cosmet Investig Dermatol. 2020 Feb 5;13:137-143. doi: 10.2147/CCID.S231940. eCollection 2020.
The association of androgenetic alopecia (AGA) with cardiovascular risk factors including hypertension, smoking and high body mass index (BMI) has been investigated in several studies. However, the results are discrepant. The aim of the present study was to evaluate the association of AGA with anthropometrics, blood pressure and lifestyle habits.
In this case-control study, 256 men with AGA and 256 age-matched healthy controls were evaluated. Systolic and diastolic blood pressures, as well as anthropometric indices were measured. Data on lifestyle habits including smoking, hookah use and alcohol consumption were also collected.
Patients with AGA had significantly lower BMI and lower waist to hip ratio as compared to controls (p = 0.012 and p = 0.002, respectively). Other anthropometrics as well as mean systolic and diastolic blood pressures were not significantly different between the two groups. There was no significant difference between patients and controls in terms of lifestyle habits. Patients with severe AGA (Norwood-Hamilton classification type IV-VII) had significantly higher systolic and diastolic blood pressures as compared to those with mild to moderate AGA (Norwood-Hamilton classification type II, III), but the mean age of the former group was also significantly higher (p < 0.001).
In contrast to some previous studies, our findings did not show a significant association between certain cardiovascular risk factors (such as hypertension and smoking) and AGA. Although lower BMI and lower waist to hip ratio were observed in the patient group, these values were within normal limits and therefore not biologically significant.
多项研究已对雄激素性脱发(AGA)与包括高血压、吸烟和高体重指数(BMI)在内的心血管危险因素之间的关联进行了调查。然而,结果并不一致。本研究的目的是评估AGA与人体测量学、血压和生活习惯之间的关联。
在这项病例对照研究中,对256名AGA男性患者和256名年龄匹配的健康对照者进行了评估。测量了收缩压和舒张压以及人体测量指标。还收集了包括吸烟、水烟使用和饮酒在内的生活习惯数据。
与对照组相比,AGA患者的BMI显著更低,腰臀比也更低(分别为p = 0.012和p = 0.002)。两组之间的其他人体测量指标以及平均收缩压和舒张压没有显著差异。患者和对照组在生活习惯方面没有显著差异。重度AGA(诺伍德 - 汉密尔顿分类IV - VII型)患者的收缩压和舒张压显著高于轻度至中度AGA(诺伍德 - 汉密尔顿分类II、III型)患者,但前一组的平均年龄也显著更高(p < 0.001)。
与之前的一些研究不同,我们的研究结果并未显示某些心血管危险因素(如高血压和吸烟)与AGA之间存在显著关联。尽管在患者组中观察到较低的BMI和较低的腰臀比,但这些值在正常范围内,因此在生物学上不具有显著意义。