Scofield R H, Racila D M, Gordon T P, Kurien B T, Sontheimer R D
Department of Medicine, University of Oklahoma Health Sciences Center, the Veterans Affairs Medical Center, and the W.K. Warren Medical Research Institute, Oklahoma City, USA.
J Rheumatol. 2000 Jan;27(1):128-34.
To examine a well characterized group of patients with systemic lupus erythematosus (SLE) for anti-calreticulin.
The sera of 77 patients with SLE were studied by immunodiffusion, solid phase immunoassay, and immunoblot for antibodies against ribonucleoprotein (RNP) autoantigens and calreticulin.
Thirty-five had anti-calreticulin and 40 had anti-60 kDa Ro. There was no association of anti-60 kDa Ro and anti-calreticulin. However, among anti-60 kDa Ro positive sera that also contained either anti-La or anti-RNP, none of 18 had anti-calreticulin. All the remaining sera with anti-60 kDa Ro had anti-calreticulin and anti-52 kDa Ro.
Anti-60 kDa Ro patients with SLE can be divided into those with anti-60 kDa Ro and either anti-La or anti-RNP or those with anti-60 kDa Ro, anti-52 kDa Ro, and anti-calreticulin.
检测一组特征明确的系统性红斑狼疮（SLE）患者的抗钙网蛋白情况。
采用免疫扩散法、固相免疫测定法和免疫印迹法，研究77例SLE患者血清中抗核糖核蛋白（RNP）自身抗原和抗钙网蛋白抗体。
35例有抗钙网蛋白，40例有抗60kDa Ro。抗60kDa Ro与抗钙网蛋白无相关性。然而，在同时含有抗La或抗RNP的抗60kDa Ro阳性血清中，18例均无抗钙网蛋白。其余所有抗60kDa Ro血清均有抗钙网蛋白和抗52kDa Ro。
SLE抗60kDa Ro患者可分为同时有抗60kDa Ro和抗La或抗RNP的患者，以及有抗60kDa Ro、抗52kDa Ro和抗钙网蛋白的患者。
