Eggleton P, Reid K B, Kishore U, Sontheimer R D
Department of Biochemistry, University of Oxford, UK.
Lupus. 1997;6(7):564-71. doi: 10.1177/096120339700600703.
Calreticulin is an abundant intracellular protein which is proposed to have numerous biological functions. However, there is increasing evidence to suggest that calreticulin plays a multifunctional role as an autoantigen present in patients with systemic lupus erythematosus. In this review we detail some of the recent evidence which indicate that calreticulin may play a supportive role in the formation of the autoantigen complex-Ro/SS-A. In addition, several proposed mechanisms of release and surface expression of calreticulin are described in relation to SLE mediated responses to the autoantigen. In particular, the generation of autoantibodies to specific regions of the protein and the ability of calreticulin to interfere with complement mediated inflammatory processes.
钙网蛋白是一种丰富的细胞内蛋白质，据推测具有多种生物学功能。然而，越来越多的证据表明，钙网蛋白作为系统性红斑狼疮患者体内存在的自身抗原发挥着多功能作用。在本综述中，我们详细介绍了一些最新证据，这些证据表明钙网蛋白可能在自身抗原复合物Ro/SS-A的形成中起支持作用。此外，还描述了几种关于钙网蛋白释放和表面表达的机制，这些机制与系统性红斑狼疮介导的对自身抗原的反应有关。特别是针对该蛋白特定区域产生自身抗体以及钙网蛋白干扰补体介导的炎症过程的能力。
