Ishida T
Department of Surgery II, Mie University School of Medicine, Tsu, Japan.
Surg Today. 2000;30(1):28-32. doi: 10.1007/PL00010042.
The CD44 variant 6 (CD44 v6) has been postulated to be involved in both carcinogenesis and tumor progression. In the present study, CD44 v6 was stained immunohistochemically in 63 colorectal cancer tissues to assess significance of CD44 v6 in the carcinogenesis and progression of colorectal carcinoma. None of the normal colonocytes showed an expression of CD44 v6. CD44 v6 expression was very strong in 24, moderate in 13, and negative in 26 tumor tissues. A negative or moderate expression of CD44 v6 was significantly associated with a larger tumor size (P < 0.05) and invasion through the bowel wall (P < 0.01). There was no correlation between the expression of CD44 v6 and gross type, histologic differentiation, lymph node involvement, liver metastasis, and clinical stage of the disease. The present study showed that the expression of CD44 v6 was characteristic of neoplastic changes in the colonocytes and that a diminished expression of CD44 v6 was associated with the penetration of colorectal cancer through the bowel wall, but not with either lymph node or distant metastasis.
CD44变异体6（CD44 v6）被推测与致癌作用和肿瘤进展均有关。在本研究中，采用免疫组织化学方法对63例结直肠癌组织中的CD44 v6进行染色，以评估CD44 v6在结直肠癌发生和进展中的意义。正常结肠细胞均未显示CD44 v6表达。在24例肿瘤组织中CD44 v6表达很强，13例中表达中等，26例中表达阴性。CD44 v6阴性或中等表达与肿瘤体积较大（P < 0.05）及肠壁浸润（P < 0.01）显著相关。CD44 v6表达与大体类型、组织学分化、淋巴结受累、肝转移及疾病临床分期之间无相关性。本研究表明，CD44 v6表达是结肠细胞肿瘤性变化的特征，CD44 v6表达降低与结直肠癌穿透肠壁有关，但与淋巴结或远处转移均无关。
