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CD44v6过表达与结直肠癌转移及不良预后相关：一项荟萃分析。

CD44v6 overexpression related to metastasis and poor prognosis of colorectal cancer: A meta-analysis.

作者信息

Wang Ji-Lin, Su Wen-Yu, Lin Yan-Wei, Xiong Hua, Chen Ying-Xuan, Xu Jie, Fang Jing-Yuan

机构信息

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China.

Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.

出版信息

Oncotarget. 2017 Feb 21;8(8):12866-12876. doi: 10.18632/oncotarget.14163.

DOI:10.18632/oncotarget.14163
PMID:28030817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5355062/
Abstract

CD44v6 has recently been reported as a biomarker for colorectal cancer. However, the clinical and prognostic significance of CD44v6 in colorectal cancer remains controversial. Therefore, we performed a meta-analysis to clarify this issue. A comprehensive literature search was performed using Medline, Embase and Web of Science, and the statistical analysis was conducted using Stata software. A total of twenty-one studies including 3918 colorectal cancer cases were included. The pooled analysis showed that CD44v6 overexpression in colorectal cancer was an independent prognostic marker correlating with lower 5-year overall survival rate (OR=0.78, 95%CI =0.67-0.91, p=0.001). CD44v6 overexpression was also associated with more lymph node invasion (OR=1.48, 95%CI= 1.02-2.15, p=0.04), and advanced Dukes stage (OR=2.47, 95%CI= 1.29-4.73, p=0.01). In addition, while excluding Zolbec's study, CD44v6 overexpression was associated with distance metastasis (OR=1.65, 95%CI =1.13-2.40, p=0.01). Taken together, this meta-analysis suggested that CD44v6 is an efficient prognostic factor in colorectal cancer.

摘要

CD44v6最近被报道为结直肠癌的一种生物标志物。然而，CD44v6在结直肠癌中的临床和预后意义仍存在争议。因此，我们进行了一项荟萃分析以阐明这个问题。使用Medline、Embase和Web of Science进行了全面的文献检索，并使用Stata软件进行了统计分析。总共纳入了21项研究，包括3918例结直肠癌病例。汇总分析表明，结直肠癌中CD44v6过表达是一个独立的预后标志物，与较低的5年总生存率相关（OR=0.78，95%CI =0.67 - 0.91，p=0.001）。CD44v6过表达还与更多的淋巴结转移（OR=1.48，95%CI= 1.02 - 2.15，p=0.04）以及Dukes分期进展（OR=2.47，95%CI= 1.29 - 4.73，p=0.01）相关。此外，在排除Zolbec的研究后，CD44v6过表达与远处转移相关（OR=1.65，95%CI =1.13 - 2.40，p=0.01）。综上所述，这项荟萃分析表明CD44v6是结直肠癌中一个有效的预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/f34a05ca7f5c/oncotarget-08-12866-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/17d4849fce2b/oncotarget-08-12866-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/d2b33a390049/oncotarget-08-12866-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/83292c9f1232/oncotarget-08-12866-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/87a67cf42df6/oncotarget-08-12866-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/50cbf62df5fe/oncotarget-08-12866-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/f34a05ca7f5c/oncotarget-08-12866-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/17d4849fce2b/oncotarget-08-12866-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/d2b33a390049/oncotarget-08-12866-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/83292c9f1232/oncotarget-08-12866-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/87a67cf42df6/oncotarget-08-12866-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/50cbf62df5fe/oncotarget-08-12866-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d902/5355062/f34a05ca7f5c/oncotarget-08-12866-g006.jpg

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