Díaz Espiñeira M M, Vink-Nooteboom M, Van den Ingh T S, Rothuizen J
Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
J Small Anim Pract. 1999 Nov;40(11):540-3. doi: 10.1111/j.1748-5827.1999.tb03016.x.
A miniature schnauzer with a history of apathy, anorexia and jaundice was presented to the Utrecht University Clinic for Companion Animals. Abnormal laboratory findings included highly increased levels of total bile acids and alkaline phosphatase, and hyponatraemia. Abdominal ultrasonography revealed that the right side of the liver was enlarged and the left side was small, together with a thrombus in the portal vein. Biopsies from the right side of the liver demonstrated subacute to chronic active hepatitis, for which the dog was treated with prednisolone (1 mg/kg/day for four weeks). No improvement was observed and the owner requested euthanasia. At necropsy the left lobes of the liver were found to be small and firm, while the right lobes were large and soft. There were two thrombi in the portal vein. Microscopic examination revealed chronic active hepatitis and cirrhosis.
一只患有冷漠、厌食和黄疸病史的迷你雪纳瑞犬被送到乌得勒支大学伴侣动物诊所。异常的实验室检查结果包括总胆汁酸和碱性磷酸酶水平大幅升高以及低钠血症。腹部超声检查显示肝脏右侧肿大而左侧较小，同时门静脉内有血栓形成。肝脏右侧的活检显示为亚急性至慢性活动性肝炎，该犬接受了泼尼松龙治疗（1毫克/千克/天，持续四周）。但未观察到病情改善，主人要求实施安乐死。尸检发现肝脏左叶小而硬，而右叶大且软。门静脉内有两个血栓。显微镜检查显示为慢性活动性肝炎和肝硬化。
