Blowey D L, Garg U C, Kearns G L, Warady B A
Department of Pediatrics, University of Missouri-Kansas City, USA.
Adv Perit Dial. 1998;14:247-50.
Fungal peritonitis is a rare event in patients receiving peritoneal dialysis. This case report describes the blood and dialysate concentrations of fluconazole and amphotericin B following intravenous administration in a 5-month-old infant with Candida albicans peritonitis receiving continuous cyclic peritoneal dialysis. Fluconazole rapidly and efficiently penetrated the peritoneal fluid achieving concentrations that exceed the minimal inhibitory concentration (MIC) for most Candida species. In contrast, the amount of amphotericin B in the dialysate was below the limit of quantification despite measurable blood concentrations. This suggests that fluconazole represents a better choice for antifungal therapy because of its excellent peritoneal penetration.
真菌性腹膜炎在接受腹膜透析的患者中是一种罕见事件。本病例报告描述了一名5个月大患有白色念珠菌性腹膜炎且接受持续循环腹膜透析的婴儿静脉注射氟康唑和两性霉素B后的血液及透析液浓度。氟康唑能快速且有效地渗透至腹膜液中，其浓度超过了大多数念珠菌属的最低抑菌浓度（MIC）。相比之下，尽管血液中两性霉素B浓度可测，但透析液中的两性霉素B含量低于定量限。这表明由于氟康唑具有出色的腹膜渗透性，它是抗真菌治疗的更佳选择。
