Successful treatment of fungal peritonitis with intracatheter antifungal retention.

Two patients who developed fungal peritonitis after receiving continuous ambulatory peritoneal dialysis (CAPD) for various periods were successfully treated with intracatheter retention of amphotericin B 1-2 mg and oral flucytosine or fluconazole 50 mg b.i.d. for 5 weeks. The catheter was not removed and efficient peritoneal permeability was maintained. We suggest that intracatheter retention of antifungal agents to sterilize the catheter with simultaneous oral antifungal agents be used to eradicate peritoneal infection. The catheter may not have to be removed, and CAPD can be accomplished. Period of hospitalization may be shortened, and the efficiency of CAPD can be maintained.