Shoemaker N J, Schuurmans M, Moorman H, Lumeij J T
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
J Am Vet Med Assoc. 2000 Jan 15;216(2):195-7. doi: 10.2460/javma.2000.216.195.
To determine prevalence of hyperadrenocorticism in ferrets in The Netherlands and evaluate age, sex, and age at neutering in affected ferrets.
Prevalence survey and retrospective study.
50 ferrets with hyperadrenocorticism and 1,267 ferrets without hyperadrenocorticism.
A questionnaire was sent to 1,400 members of a ferret-owners organization in The Netherlands; 492 (35%) owners returned the questionnaire, providing usable data on 1,274 ferrets. Seven of these ferrets developed hyperadrenocorticism during the survey period; medical records for these ferrets and 43 ferrets with confirmed hyperadrenocorticism were reviewed. Hyperadrenocorticism was confirmed by histologic examination of an excised adrenal gland (92% of ferrets) or clinical improvement after excision.
Prevalence of hyperadrenocorticism in the survey population was 0.55%. Sex was not associated with prevalence of disease. Median time interval between neutering and diagnosis of hyperadrenocorticism was 3.5 years. A significant linear correlation between age at neutering and age at time of diagnosis was detected.
Age at neutering may be associated with age at development of hyperadrenocorticism in ferrets.
确定荷兰雪貂肾上腺皮质功能亢进症的患病率，并评估患病雪貂的年龄、性别及绝育时的年龄。
患病率调查及回顾性研究。
50只患有肾上腺皮质功能亢进症的雪貂和1267只未患肾上腺皮质功能亢进症的雪貂。
向荷兰一个雪貂饲养者组织的1400名成员发送调查问卷；492名（35%）饲养者回复了问卷，提供了1274只雪貂的可用数据。在调查期间，这些雪貂中有7只患上了肾上腺皮质功能亢进症；对这些雪貂以及43只确诊患有肾上腺皮质功能亢进症的雪貂的病历进行了审查。肾上腺皮质功能亢进症通过切除肾上腺的组织学检查（92%的雪貂）或切除术后的临床改善得以确诊。
调查人群中肾上腺皮质功能亢进症的患病率为0.55%。性别与疾病患病率无关。绝育至肾上腺皮质功能亢进症诊断的中位时间间隔为3.5年。检测到绝育时的年龄与诊断时的年龄之间存在显著的线性相关性。
绝育时的年龄可能与雪貂患肾上腺皮质功能亢进症时的年龄有关。
