外毛细胞质膜中电压和张力依赖性脂质流动性
Voltage- and tension-dependent lipid mobility in the outer hair cell plasma membrane.
作者信息
Oghalai J S, Zhao H B, Kutz J W, Brownell W E
机构信息
Department of Otolaryngology and Communicative Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
出版信息
Science. 2000 Jan 28;287(5453):658-61. doi: 10.1126/science.287.5453.658.
Abstract
The mechanism responsible for electromotility of outer hair cells in the ear is unknown but is thought to reside within the plasma membrane. Lipid lateral diffusion in the outer hair cell plasma membrane is a sigmoidal function of transmembrane potential and bathing media osmolality. Cell depolarization or hyposmotic challenge shorten the cell and reduce membrane fluidity by half. Changing the membrane tension with amphipathic drugs results in similar reductions. These dynamic changes in membrane fluidity represent the modulation of membrane tension by lipid-protein interactions. The voltage dependence may be associated with the force-generating motors that contribute to the exquisite sensitivity of mammalian hearing.
摘要
耳中外毛细胞电运动的机制尚不清楚，但被认为存在于质膜内。外毛细胞质膜中的脂质侧向扩散是跨膜电位和浸浴介质渗透压的S形函数。细胞去极化或低渗刺激会使细胞缩短，并使膜流动性降低一半。用两亲性药物改变膜张力会导致类似的降低。膜流动性的这些动态变化代表了脂质-蛋白质相互作用对膜张力的调节。电压依赖性可能与有助于哺乳动物听力极高灵敏度的力产生马达有关。
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