Cichewicz R H, Kouzi S A, Hamann M T
Division of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA.
J Nat Prod. 2000 Jan;63(1):29-33. doi: 10.1021/np990266n.
Resveratrol (trans-3,4',5-trihydroxystilbene) is produced by grapes (Vitis spp.) in response to microbial attack by the fungal grapevine pathogen Botrytis cinerea. Several reports indicate that pathogenic B.cinerea strains are capable of biotransforming resveratrol into an assortment of unidentified oxidized metabolites as a means of reducing the antifungal effects of resveratrol and facilitating Botrytis invasion into host-plant tissues. Studies utilizing growing incubations of Botrytis cinerea ATCC 11542 with resveratrol resulted in the production of three new (restrytisols A-C) (1-3) and three known (resveratrol trans-dehydrodimer, leachinol F, and pallidol) oxidized resveratrol dimers. All of the metabolites were evaluated for their anti-HIV-1, cytotoxic, and cyclooxygenase (COX) I and COX II inhibitory activities.
白藜芦醇（反式-3,4',5-三羟基芪）由葡萄（葡萄属）产生，以应对葡萄真菌病原体灰葡萄孢的微生物攻击。几份报告表明，致病的灰葡萄孢菌株能够将白藜芦醇生物转化为多种未鉴定的氧化代谢物，以此降低白藜芦醇的抗真菌作用，并促进灰葡萄孢侵入宿主植物组织。利用灰葡萄孢ATCC 11542与白藜芦醇进行培养的研究产生了三种新的（灰葡萄孢醇A-C）（1-3）和三种已知的（白藜芦醇反式脱氢二聚体、刺囊酸F和苍白酚）氧化白藜芦醇二聚体。对所有代谢物的抗HIV-1、细胞毒性以及环氧化酶（COX）I和COX II抑制活性进行了评估。
