Wellington K D, Cambie R C, Rutledge P S, Bergquist P R
Department of Chemistry, and School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
J Nat Prod. 2000 Jan;63(1):79-85. doi: 10.1021/np9903494.
Seven new compounds (1-6 and 10) with a unique carbon skeleton have been isolated from the sponge Hamigera tarangaensis, and the structure of a previously reported metabolite has been revised from 12 to 8. The structures have been assigned from extensive NMR examination. Compounds 3-6 showed moderate in-vitro cytotoxicity against P-388, while 3 showed 100% in-vitro virus inhibition against both the Herpes and Polio viruses, with only slight cytotoxicity.
从海绵Tarangaensis中分离出七种具有独特碳骨架的新化合物（1-6和10），并且已将先前报道的一种代谢物的结构从12修正为8。通过广泛的核磁共振检查确定了这些结构。化合物3-6对P-388显示出中等程度的体外细胞毒性，而化合物3对疱疹病毒和脊髓灰质炎病毒均显示出100%的体外病毒抑制作用，且细胞毒性轻微。
